New studies say that gut microbes have a key role in helping people to reduce weight. A research study among mice observed that through gastric bypass surgery, weight loss can be achieved. It is by a reduction of stomach size and altering the overall microbial population composition. According to the next study, people with higher methane creating microbes can be heavier and feature a massive percentage of fats.
The discoveries can drive microbe powered approaches towards weight loss. It has been a field where drug development is seemingly difficult. Few years back, while the microbiome study was initially unfolding, researchers observed that gut microbe population varies in composition among mice and people who are overweight and lean. Microbes varied accordingly while losing weight. Whenever the gut microbes of overweight individuals were transferred inside mice with zero microbes, they gained weight more than while treated with the microbes out of lean people.
There is more evidence with Lee Kaplan and Harvard associates that microbes may help in controlling weight. Similarly, they could play an important role in among the vastly successful treatments for weight loss available. Scientists have hints that advantages of gastric bypass surgery do not include just a drop in terms of calories consumed. According to Kaplan, certain sides of evidence point out that it functions by altering the key mechanism of metabolic function and energy balance. Research in the past suggested that both among humans and rodents, the process changes the microbes inside the gut although it hasn’t displayed to be influencing weight.
According to a new study which published in a medical journal, researchers studied triple groups of the obese mice treated with high fats diet. One of the groups went through a process same as gastric bypass, losing 30% of their physical mass. The other two groups went through a fake procedure where incision was made without altering the anatomy. Normal diet was fed to one of the mice groups that regained weight post surgery period. The other groups lose weight while undergoing a prescribed diet and also lost weight same as gastric bypass group. Bypass animals consumed the same proportion as nicely fed control animals. However, they seemingly spend more energy.
Prior to and post the procedure, researchers analyzed the DNA of fecal samples. They observed that gut microbes were affected significantly by gastric bypass. There was also a rise in Gammaproteobacteria and Verrucomicrobia bacteria based on changes observed among the people post the bypass period. Transporting gut microbes out of surgically changed mice into the microbe less animals resulted in weight loss. Animals that were vaccinated with microbes out of two different control groups did not change weight.
The aforementioned findings trigger curiousness on ways to reap gastric bypass benefits without surgery. Scientists need to find out the microbes that triggers weight loss. A hypothesis point out that they affect the energy expenditure of body- the calories burned by merely sitting around. Researchers are reportedly testing the outcomes of changing levels of the individual microbes and the chemicals produced by them.